So I thought of this the other day. That show foster's home for imaginary friends.
It has been stated in the show. Kid's can bring imaginary friends to life. Now, what if that was not true. Instead Mac and Bloo are friends with some unstabiltiy. Bloo could be an extreme narcissist who has anger issues, and other things that could make him a unfit for a normal society. While Mac could be delusional and see some people as things they are not or imaginary friends. Mac mental condition is not that bad and possibly fought off by medication. So he has to make daily checks to 'Foster's home' and to visit his friend Bloo.
Mac may also have a condition which is triggered by sugar. He because a psychotic creature when on sugar. this could just be a sugar rush to the extreme but it's possible that his medication may react negatively and create more vivid hallucinations when sugar is in the system.
Franky Foster is a nurse maid and possibly a big person in charge. Her behavior is she enjoys the building and likes the inhabitants but she like many people is annoyed by others from time to time.
Mr. Herrimen is either a crazy person who he thinks he is extremely sophisticated but won't wear pants. OR he could be a major administrator and Franky's boss with a large mustache.
Madam Foster, is either the woman in charge or an old patient and Franky works there to see her crazy grandmother.
Edwardo could be a large hairy man, who speaks Spanish, but has a crippling paranoia and possible anger issues. As we see in the show he is a big coward and does go on rampages when something seems wrong.
Wilt could be a really tall man who is physically deformed. In a movie it's shown his arm was crushed and his eye busted. It is possible he had something take his eye and arm. Add on the fact he may have OCD or something making him be sorry for everything and a walking doormat.
Coco could be a crazy woman who may be rich. She may go around buying things and giving them to random people as gifts, or she is a kleptomaniac who likes to take random objects and leave them around.
Dutchess may be a former wealthy woman, who went crazy when loosing all her wealth making her believe she is still wealthy and act like she still has money.
Mac's mother may be a normal woman who just wants her son to be OK. Bloo being a possibly more dangerous person then Mac, she would want him and Bloo seperated.
Goo is probably a crazy girl I don't think this is even hidden in the show. With a similar condition to Mac, and she may have a less severe condition then Mac so she doesn't have to return daily like him.
Terrance, I see him in two ways for this theory. 1) He refuses to accept Mac is crazy at all and wants to keep him away from Foster's home afraid they'll make him seem crazier. 2) Terrance could have a bigot mindset and see someone crazy as a hindrance on humanity, he may torture Mac because he thinks Mac is an impure human.
Berry is pretty simple. A psychotic girl, who is obsessed with some people she falls in love with. When she was kicked out of the house it may be Bloo got a restraining order and she had to be sent to another facility.
Cheese is probably a severally mentally challenged child who has condition capable of placing him inside of the foster home. Instead his family keeps care of him themselves to keep him close and possibly out of public attention.